Buy Tetrahydrofuran (THF) Liquid CAS 109-99-9 — Industrial & Lab Grade Solvent

Buy Tetrahydrofuran (THF) Liquid CAS 109-99-9 — Industrial & Lab Grade Solvent
Tetrahydrofuran (THF) is a highly versatile cyclic ether 
solvent and one of the most important polar aprotic solvents 
in industrial chemistry and laboratory science. Produced 
commercially from 1,4-Butanediol (BDO) via acid-catalysed 
dehydration, THF combines complete water miscibility with 
exceptional solvency for a broad range of polymers, resins, 
and organic compounds — a combination that makes it 
irreplaceable across polymer processing, pharmaceutical 
synthesis, analytical chemistry, and PVC fabrication.

THF occupies a unique position in the solvent landscape: 
it is one of very few solvents that is both water-miscible 
and capable of dissolving non-polar polymers including PVC, 
polyurethanes, polystyrene, and specialty engineering 
resins. This dual solvency characteristic makes it 
invaluable in applications where conventional solvents 
fail to bridge polar and non-polar chemistry requirements.
Chemical Properties & Technical Specifications

CAS Number: 109-99-9
Other Names: THF, Oxolane, Cyclotetramethylene Oxide, 
 Butylene Oxide, 1,4-Epoxybutane
Molecular Formula: C4H8O
Molar Mass: 72.11 g/mol
Physical Form: Liquid
Appearance: Colourless, clear, highly mobile liquid
Odour: Pleasant, characteristic ether-like odour
Density: 0.889 g/cm3 at 20 deg C
Boiling Point: 66 deg C (151 deg F)
Melting Point: -108 deg C (-162 deg F)
Flash Point: -14 deg C (7 deg F) — HIGHLY FLAMMABLE
Auto-ignition Temperature: 321 deg C (610 deg F)
Explosive Limits: 1.5% - 12.4% v/v in air
Vapour Pressure: 194 hPa at 20 deg C
Refractive Index: 1.405 - 1.407
Viscosity: 0.55 mPa.s at 20 deg C
Dielectric Constant: 7.6 at 22 deg C
Solubility: Fully miscible with water and most 
            organic solvents
Log Pow (octanol/water): 0.46
Purity: >=99.5% (industrial and laboratory grade)
Inhibitor: BHT added to prevent peroxide formation
Peroxide Content: <10 ppm (fresh supply)
Water Content: <0.05%
UN Number: UN 2056 — Highly Flammable Liquid Class 3
Packing Group: II

Critical Safety Note — Peroxide Formation

THF is classified as a peroxide-forming solvent. On 
prolonged exposure to air, light, and oxygen, THF 
spontaneously forms explosive organic peroxides that 
accumulate in the liquid and concentrate in residues 
on evaporation. This is one of the most serious 
laboratory hazards associated with ether solvents.

Key peroxide safety rules:
- Always use THF supplied with a BHT inhibitor
- Check peroxide content before distillation or 
  concentration operations
- Never distill THF to dryness
- Test for peroxides every 3-6 months during storage
- Discard THF showing peroxide content >25 ppm
- Store in tightly sealed containers under inert 
  atmosphere where possible
- Never use THF from containers that have been 
  previously opened and stored long-term without 
  peroxide testing
Primary Industrial Applications

1. Polymer Dissolution and Processing
THF is the standard solvent for dissolving and processing 
PVC (polyvinyl chloride), polyurethanes, polystyrene, 
polymethyl methacrylate (PMMA), and a wide range of 
specialty engineering polymers. In polymer research and 
quality control, THF is used to prepare polymer solutions 
for gel permeation chromatography (GPC) molecular weight 
analysis — the standard technique for characterising 
polymer molecular weight distribution in the plastics 
and polymer industry.

2. PVC Pipe and Fitting Fabrication
THF is a primary component in PVC solvent cement 
formulations used for joining PVC pressure pipe and 
fittings in plumbing, irrigation, and industrial piping 
systems. The THF dissolves the PVC surfaces being joined, 
allowing molecular-level fusion that creates a joint 
stronger than the pipe wall itself. This application 
represents a major volume end-use for THF in the 
construction and infrastructure sectors.

3. Pharmaceutical Synthesis
THF is widely used as a reaction solvent in pharmaceutical 
synthesis for reactions requiring a polar aprotic medium 
with good solubility for both organic substrates and 
inorganic reagents. Its relatively low boiling point 
(66 deg C) makes it easy to remove by evaporation after 
reaction, simplifying product isolation. It is also used 
as an extraction solvent in pharmaceutical API isolation 
and purification processes.
4. HPLC and Analytical Chemistry
THF is a standard modifier in reverse-phase HPLC mobile 
phase systems, used to adjust selectivity and elution 
strength in chromatographic method development. Its UV 
cutoff of approximately 220 nm allows use with UV 
detectors in most analytical wavelength ranges. It is 
also used as a GPC/SEC solvent for polymer molecular 
weight analysis.
5. Adhesive and Coating Formulation
THF is used as a solvent in specialty adhesive and 
coating formulations where its fast evaporation rate 
and excellent polymer solvency are advantageous. 
Applications include contact adhesives, structural 
adhesive systems, specialty protective coatings, and 
laminating adhesives for flexible packaging.
6. Chemical Synthesis
THF is an important reaction solvent and chemical 
intermediate in organic synthesis. It is used as the 
reaction medium for Grignard reactions, metal hydride 
reductions (LiAlH4, NaBH4), organolithium chemistry, 
and a broad range of polar aprotic reaction systems 
in pharmaceutical and specialty chemical manufacturing.
Storage Requirements
Store in tightly sealed, UN-approved containers under 
inert gas (nitrogen) blanket at 5-25 deg C away from 
all ignition sources, heat, and direct sunlight. Keep 
in a dedicated flammable solvent storage cabinet. 
Maintain BHT inhibitor concentration — add fresh BHT 
if inhibitor level has degraded. Test for peroxide 
content every 3-6 months. Do not store in 
previously opened containers for extended periods 
without peroxide testing. UN 2056 transport 
regulations apply to all shipments.
 
Order Information

Tetrahydrofuran (THF) is available from UAB An Group 
Export in the following configurations:
- Sample orders: 1L and 5L units — $160.00 per litre
- Bulk orders: 20L, 100L, and pallet quantities
- Custom volumes available on request for ongoing 
  supply contracts

Contact us at info@angroupexport.com or via WhatsApp 
at +1 (350) 210-1380 to request a quote or discuss 
your supply requirements.